Sloppy science & good read

I’m packing for vacation. The book that I will NOT pack is: Rigor Mortis, how sloppy science creates worthless cures, crushes hope and wastes billions by Richard Harris. I read it already two times, and anyone interested in science, or trying to deliver a piece of it once in a while, should read it. It makes you realise what we do, what we publish and what we read. And then, it makes you humble (or sad, or furious, or happy). Continue reading

Agent Orange in spinal surgery

This week I learned from an orthopaedic surgeon that randomized trials were something that could be of use in “pharmaceutical sciences”, but that it is well-known that in the “surgical science” retrospective analyses are better for deriving evidence. We came to this when discussing the benefits of powdered vancomycin in the wounds of spinal surgery. Apparently this is something “all spinal orthopaedics do”, because it works so good. Continue reading

How to predict ESBL (part 3)

Six weeks ago I introduced the ESBL-predict study that Tim Deelen from our group coordinates. Every hospital in the world can participate through a user-friendly electronic CRF (in a secured environment). My blog-invitation to particpate worked and some sites already started. In June >1,000 episodes were entered! Here is a short update and info for those that want to join.  Continue reading

Exposed: Dutch clinical microbiologists

Exposed; that’s what we are. We, Dutch clinical microbiologists. Globally acknowledged for our capacity to control antibiotic resistance, prevent hospital-acquired infections (HAI) and practice the most rational and restrictive antibiotic policies. That we are self-confident, loud and arrogant  is taken for granted, as most do with Christiano Ronaldo. But it is with great sadness that I have to announce that it was all FAKE. The balloon was pricked by professor Marcel Levi. Continue reading

Real-time whole genome sequencing (RT-WGS) & spread of resistant bacteria

At last weeks’ ICPIC I crossed arguments with John Rossen on the question whether RT-WGS helps us to control the spread of resistant bacteria. The setting is the hospital and the definition of RT is “in time to guide essential decision making”. Is RT-WGS a “need-to-have” or a “nice-to-have” thing? Continue reading

The rocket-science of a CPE screen & isolate policy

Last weeks’ blog from Jon Otter on the practice of CPE screening and isolation raised some interesting comments (on twitter) emphasizing the difficulties in policy making for infection control. The two comments that struck me were: (1) … screening for CPE sounds logical “but does it work in long-term care facilities with high-levels of endemicity?” And “I use it in my hospital, but face difficulties in convincing others because of lacking scientific evidence for CPE.” Continue reading

LA-MRSA: On the definition of emergence

Some friends, called patriotic hackers, had secured a very interesting surveillance database and I tried to write a manuscript, when I was scooped (in CID) by friends that apparently had access to the same database. That made my work redundant. So, for your eyes only, my take on that data. Continue reading