Genetic susceptibility for rotavirus infection

Each week our PhD students have their own Journal Club. Apparently they recently developed an interest in http://www.reflectionsipc and asked whether I was interested in getting their input. What a great idea, I thought, and here is the first one. Josephine van Dongen discussed a Scientific Reports paper on acute gastroenteritis (AGE) due to rotavirus. A global burden among children, but it can be prevented effectively by vaccination (still not recommended in our country!). Rotavirus discriminates: if your genes encode your cells to have a “secretor status” or being “Lewis positive” your infection risk increases (there even is a meta-analysis, for those still in doubt). And you are more likely to have these genotypes (at least secretor) if you’re Asian. Whether genotypes also predispose for more severe infection is unknown, and that’s what the study was about. Continue reading

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