When’s the last time you picked your nose? If you’re an adult, it was very probably earlier today – the average adult picks their nose around 4 times per day (eew). And that’s picking – touching is much more frequent: on average, we touch our eyes, mouth, nose, or chin a staggering 20 times per hour (with some estimates even higher). We’ve known for a while that nasal decolonisation is a vital component in reducing the risk of staphylococcal infection. But using mupirocin as the nasal decolonisation agent has important limitations in terms of spectrum of microbiological efficacy, compliance, and antibiotic resistance. I’ve recently come across a newer technology for nasal decolonisation: nasal photodisinfection. It’s been around for ages, but hasn’t really been adopted widely. This blog provides an overview of three studies that suggest nasal photodisinfection may have a role in reducing the risk of SSI, and in preventing and treating SARS-CoV-2 infection.